解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We investigated regional grey matter (GM) density in adolescents with Down syndrome (DS) compared to age-matched controls and correlated MRI data with neuropsychological measures in the DS group. Inter-group comparisons documented several GM concentration abnormalities in the participants with DS compared to controls....
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-011-9448-3
更新日期:2011-05-01 00:00:00
abstract::Chickens homozygous for the Dominant white or wild-type allele of PMEL17 were subjected to a broad phenotyping in order to detect consistent differences between genotypes. To exclude feather pecking, the chickens were individually housed without physical contact, from the day of hatching, and tested for social, aggres...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9379-4
更新日期:2011-03-01 00:00:00
abstract::We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m(3)) and body mass index (BMI, kg/m(2)) from 1 to 11 years of age were used. Additive genetic factors explained the ma...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9380-y
更新日期:2011-03-01 00:00:00
abstract::Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between si...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9385-6
更新日期:2011-03-01 00:00:00
abstract::The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2)...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9387-4
更新日期:2011-03-01 00:00:00
abstract::The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9402-9
更新日期:2011-01-01 00:00:00
abstract::Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candi...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-011-9444-7
更新日期:2011-01-01 00:00:00
abstract::Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9365-x
更新日期:2010-09-01 00:00:00
abstract::Voluntary physical activity may be related to personality traits. Here, we investigated these relations in two mouse lines selectively bred for high voluntary wheel-running behavior and in one non-selected control line. Selection lines were more explorative and "information gathering" in the open-field test, either wi...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9359-8
更新日期:2010-07-01 00:00:00
abstract::Inhibitory control (IC) is a dimension of child temperament that emerges in toddlerhood and involves the ability to regulate behavior in response to instructions or expectations. In general, children with low levels of IC have more cognitive and social difficulties, and higher levels of problem behaviors. Unfortunatel...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9316-6
更新日期:2010-05-01 00:00:00
abstract::Knowledge about the proportion of markers without effects (p( 0 )) and the effect sizes in large scale genetic studies is important to understand the basic properties of the data and for applications such as the control of false discoveries and designing adequately powered replication studies. Many p(0) estimators hav...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9321-9
更新日期:2010-05-01 00:00:00
abstract::Using high resolution magnetic resonance imaging data, we examined the interrelationships between eight cerebral lobar volumetric measures via both exploratory and confirmatory factor analyses in a large sample (N = 484) of pediatric twins and singletons. These analyses suggest the presence of strong genetic correlati...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9332-6
更新日期:2010-03-01 00:00:00
abstract::Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with soci...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9308-6
更新日期:2010-01-01 00:00:00
abstract::Taste perception allows most animals to find edible food, potential mates, and avoid ingesting toxic molecules. Intriguingly, a small group of Drosophila taste neurones (expressing Gr66a-Gal4) involved in the perception of bitter substances is also used to detect 7-tricosene (7-T), a male cuticular pheromone. Male fli...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9286-8
更新日期:2009-09-01 00:00:00
abstract::The concept of generalist genes operating across diverse domains of cognitive abilities is now widely accepted. Much less is known about the etiology of the high extreme of performance. Is there more specialization at the high extreme? Using a representative sample of 4,000 12-year-old twin pairs from the UK Twins Ear...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9271-2
更新日期:2009-07-01 00:00:00
abstract::In this article, we successfully apply the novel model selection method, Bayesian composite model space approach which has been used to map quantitative trait loci (QTL) for allelic substitution model, to map QTL for variance component model. The novel model selection approach has two advantages compared to the revers...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9259-y
更新日期:2009-05-01 00:00:00
abstract::In this study we analyzed the etiology of the relationship between personality traits and retrospectively recalled family environment. The data of 226 identical and 168 fraternal twin pairs reared together from the Jena twin study of social attitudes were available. Personality traits were measured using the self- and...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9238-8
更新日期:2009-01-01 00:00:00
abstract::Mating behavior, including courtship and copulation, is a main component of male fitness, especially in species with no parental care. Variation in this behavior can thus be a target for mate choice and sexual selection, and can lead to evolution. The fruit fly, Drosophila melanogaster, has well-documented complex mal...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9204-5
更新日期:2008-07-01 00:00:00
abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9197-0
更新日期:2008-05-01 00:00:00
abstract::Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9183-y
更新日期:2008-03-01 00:00:00
abstract::Heritability estimates of birth weight have been inconsistent. Possible explanations are heritability changes during gestational age or the influence of covariates (e.g. chorionicity). The aim of this study was to model birth weights of twins across gestational age and to quantify the genetic and environmental compone...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9170-3
更新日期:2008-01-01 00:00:00
abstract::Genes involved in melatonin synthesis, such as Aa-nat, may be important for our understanding of diurnal preference and circadian rhythm disturbances in humans. In Japan, Hohjoh et al. reported increased allelic frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syn...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9155-2
更新日期:2007-07-01 00:00:00
abstract::Twin studies are useful for assessing the relative importance of genetic or heritable component from the environmental component. In this paper we develop a methodology to study the heritability of age-at-onset or lifespan traits, with application to analysis of twin survival data. Due to limited period of observation...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9150-7
更新日期:2007-07-01 00:00:00
abstract::For many psychiatric conditions it is speculated that, rather than being single disease entities, they are a set of several disorders sharing clinical features but having (partly) different underlying causes. The possibility of measuring genetic variation on a large scale has given researchers new hope of identifying ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9135-y
更新日期:2007-05-01 00:00:00
abstract::Latent variable models are used in biological and social sciences to investigate characteristics that are not directly measurable. The generation of individual scores of latent variables can simplify subsequent analyses. However, missing measurements in real data complicate the calculation of scores. Missing observati...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9123-2
更新日期:2007-03-01 00:00:00
abstract::The prevalence of marriage varies across the lifespan, as does its importance to reproduction and the nurturance of children. We examined genetic and environmental influences on self-reported marriage at each decade from 20 through 70 years of age, using data collected for the Duke Dementia Study, a followed-up subset...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9132-1
更新日期:2007-03-01 00:00:00
abstract::The amygdala integrates and coordinates emotional and autonomic responses. The genetics that underlie variation in amygdala structure may be coupled to variation in levels of aggression, fear, anxiety, and affiliated behaviors. We systematically quantified the volume and cell populations of the basolateral amygdala co...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9122-3
更新日期:2007-01-01 00:00:00
abstract::The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9084-5
更新日期:2006-11-01 00:00:00
abstract::Parameter estimates from analyses of univariate twin data usually do not reflect the uncertainty due to the model selection phase of the data analysis. To address the effect of model selection uncertainty on parameter estimates, we introduce frequentist model-averaged estimators for univariate twin data analysis that ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9065-8
更新日期:2006-09-01 00:00:00
abstract::: We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what exte...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9022-y
更新日期:2006-03-01 00:00:00
abstract::The Inositol 1,4,5-triphosphate (IP3) route is one of the two main transduction cascades that mediate olfactory reception in Drosophila melanogaster. The activity of IP3 kinase1 reduces the levels of this substrate by phosphorylation into inositol 1,3,4,5-tetrakiphosphate (IP4). We show here that the gene is expressed...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9031-x
更新日期:2006-03-01 00:00:00
abstract::A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual R...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9003-1
更新日期:2006-01-01 00:00:00
abstract::A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, ...
journal_title:Behavior genetics
pub_type: 杂志文章,多中心研究
doi:10.1007/s10519-005-9006-y
更新日期:2006-01-01 00:00:00
abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-6119-2
更新日期:2005-11-01 00:00:00
abstract::Recent substantive research on biometric analyses of twin and family data has used both a biometric path analysis model (PAM) and a biometric variance components model (VCM). Methodological research on these same topics have suggested benefits of using linear structural equation model algorithms (SEMA) as well as mixe...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-2868-1
更新日期:2005-09-01 00:00:00
abstract::We examined longitudinally collected behavioral reports by teachers on a unique twin sample at the ages of 7, 8, 9, 10, 11, and 12 years. As twin and adoption studies implicate the role of genetic influence on behavioral problems found to be stable in epidemiological samples, the current study employs a developmental ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-004-1747-5
更新日期:2005-07-01 00:00:00
abstract::Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorp...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-2791-5
更新日期:2005-07-01 00:00:00
abstract::Courtship song serves as a sexual signal and may contribute to reproductive isolation between closely related species. Using lines of Drosophila pseudoobscura experimentally selected under different sexual selection regimes, we tested whether increased promiscuity and enforced monogamy led to evolutionary changes in c...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-3217-0
更新日期:2005-05-01 00:00:00
abstract::This is the first report of data analyses from a consortium of longitudinal genetic-risk studies on offspring of schizophrenic parents (CLOSSER) who were followed from birth or mid-childhood to their early 20's or considerably older ages. Three of the CLOSSER studies provide data to enable us to address long-persistin...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-005-3227-y
更新日期:2005-05-01 00:00:00
abstract::Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-004-1017-6
更新日期:2005-03-01 00:00:00